Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 49, Issue 4, Pages 480-483Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.49.480
Keywords
leishmaniasis; 2-propyltrifluoromethylquinoline; 2-epoxypropyltrifluoromethylquinoline; 2-(propen-1-yl)-trifluoromethylquinoline
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The synthesis of 2-substituted-trifluoromethylquinolines from aniline, trifluoromethylanilines, 3-amino-quinoline and trifluoromethylquinaldines is reported. In vitro antileishmanial evaluation of 2-alkyl, 2-alkenyl and 2-epoxypropyl-trifluoromethylquinolines is presented.
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