Journal
BIOCHEMISTRY
Volume 52, Issue 22, Pages 3818-3828Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi301519p
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Funding
- National Heart, Lung, and Blood Institute [5RL1HL092551-05]
- National Institute of General Medical Science [5R01 GM058008-14]
- National Institutes of Health [8 P41 GM103391-02]
- National Center for Advancing Translational Sciences of the National Institute of Health [UL1 TR000445]
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Matrix-assisted laser desorption ionization imaging mass spectrometry (IMS) is a relatively new imaging modality that allows Mapping of a wide range of biomolecules within a thin tissue section. The technology uses a laser beam to directly desorb and ionize molecules from discrete locations on the tissue that are subsequently recorded in a mass spectrometer. IMS is distinguished by the ability to directly measure molecules in situ ranging from small, metabolites to proteins, reporting hundreds to thousands of expression patterns from a single imaging experiment. This article reviews recent advances in IMS technology, applications, and experimental strategies that allow it to significantly aid in the discovery and understanding of molecular processes in biological and clinical samples.
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