Journal
AMERICAN JOURNAL OF HYPERTENSION
Volume 14, Issue 4, Pages 377-381Publisher
OXFORD UNIV PRESS
DOI: 10.1016/S0895-7061(00)01298-X
Keywords
allicin; garlic; blood pressure; insulin; triglycerides; Sprague-Dawley rats
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The effects of a synthetic preparation of an active constituent of garlic, allicin, were studied on blood pressure (BP), triglycericles, and insulin levels in Sprague-Dawley rats in which high fructose feeding elicited hyperinsulinemia, hypertension, and hypertriglyceridemia. Results were compared with those of the antihypertensive drug enalapril. Three groups of male Sprague-Dawley rats were fed a fructose-enriched diet for 5 weeks. During the last 2 weeks 10 animals received only fructose, IO received allicin, and 10 received enalapril. Blood pressure, insulin level, and triglyceride levels were measured at the beginning of the experiment and after a and 5 weeks on the fructose diet, fructose/allicin diet, or fructose/enalapril diet. Allicin lowered BP from the maximal level (after 3 weeks of fructose) of 153.4 +/- 8 mm Hg to 139.7 +/- 12 mm Hg after 2 weeks on allicin; insulin from 11.7 +/- 3.7 ng/mL on fructose diet to 6.92 +/- 3.3 ng/mL on allicin; and triglycerides from 132.8 +/- 18 mg/dL on fructose to 59.6 +/- 27 mg/dL on allicin. The similar effect of allicin and enalapril on BP, insulin, and triglycerides reinforces the trend toward combining the nonpharmacologic approach with drug therapy. (C) 2001 American Journal of Hypertension, Ltd.
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