Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 25, Issue 1, Pages 3-7Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0731-7085(00)00459-3
Keywords
atomic absorption spectrometry; potassium tetraiodomercate; atropine; diphenhydroamine; tolazine; levamisole
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Ion-associate complexes of atropine sulphate (I), diphenhydramine HCl (II), tolazoline HCl (III) and levamisole HCl (IV) with potassium tetraiodomercurate were precipitated and their solubilities were studied as a function of pH, ionic strength and temperature. Saturated solutions of each ion-associate under the optimum precipitation conditions were prepared and the metal ion-content in the supernatant was determined. The solubility products were thus calculated at different temperatures. A new accurate acid precise method using atomic absorption spectrometry for the determination of the investigated drugs in pure solutions and in pharmaceutical preparations is described. The drugs can be determined by the present method in the ranges 13.6-138.8, 5.6-58, 3.6-39.6 and 4.8-48 mug/ml solutions of I-IV, respectively. (C) 2001 Elsevier Science B.V. All rights reserved.
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