Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 33, Issue 4, Pages 639-650Publisher
ELSEVIER SCI LTD
DOI: 10.1006/jmcc.2000.1354
Keywords
L-type Ca2+ channels; facilitation; inactivation; calmodulin kinase; ICP domain; calmodulin binding domain
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Funding
- NHLBI NIH HHS [HL03727, HL62494] Funding Source: Medline
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Ca2+ entry (I-Ca) through cardiac L-type Ca2+ channels (LTCC) drives critical cellular processes ranging from contraction to gene expression, and. when disordered, is implicated in arrhythmias and hypertrophy, LTCC activation occurs by cell membrane depolarization, but LTCCs are also regulated by auxiliary proteins. phosphorylation, and intracellular Ca2+ ([Ca2+](i)). LTCC regulation by [Ca2+](i) is especially intriguing because increased [Ca2+](i) signals dual and conflicting commands for I-Ca inactivation and facilitation. A recent explosion of work has shed new light on the mechanisms and molecular identity of domains necessary for [Ca2+](i)-dependent regulation of LTCC. (C) 2001 Academic Press.
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