Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 7, Pages 3488-3489Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.7.3488-3489.2001
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Funding
- NIAID NIH HHS [R01 AI039975, AI39975-01, AI36555] Funding Source: Medline
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A member of the human endogenous retrovirus (HERV) family termed HERV-W encodes a highly fusogenic membrane glycoprotein that appears to be expressed specifically in the placenta. It is unclear whether the glycoproteins of the HERVs can serve as functional retrovirus envelope proteins to confer infectivity on retrovirus particles. We found that the HERV-W envelope glycoprotein can form pseudotypes with human immunodeficiency virus type 1 virions and confers tropism for CD4-negative cells. Thus, the HERV-W env gene represents the first HERV env gene demonstrated to encode the functional properties of a retrovirus envelope glycoprotein.
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