Journal
PEDIATRICS
Volume 107, Issue 4, Pages art. no.-e48Publisher
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.107.4.e48
Keywords
interferon gamma; mycobacteria; genetic susceptibility; immunodeficiency; plasma
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We have found that children with complete interferon gamma (IFN gamma) receptor deficiency, unlike patients with other genetic defects predisposing them to mycobacterial diseases, have very high levels of IFN gamma in their plasma. This unexpected observation provides a simple and accurate diagnostic method for complete IFN gamma receptor deficiency in children with clinical disease caused by bacille Calmette-Guerin vaccines or environmental nontuberculous mycobacteria.
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