Journal
TRENDS IN IMMUNOLOGY
Volume 22, Issue 4, Pages 187-191Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(01)01869-5
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Primary immune responses are initiated by specific physical interaction of antigen-specific T cells and professional antigen-presenting cells (APCs). Productive interactions can be a dynamic process that combines physical T-cell binding to APCs with vigorous crawling across and scanning of the APC surface, resulting in signal induction. After T-cell detachment, subsequent migratory contacts to the same or neighboring dendritic cells (DCs) allow the accumulation of sequential signals and interaction time. Here, we develop a serial encounter model of T-cell activation and discuss how the summation of multiple signals provides an efficient strategy to control an ongoing immune response.
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