Journal
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
Volume 189, Issue 3, Pages 127-131Publisher
SPRINGER-VERLAG
DOI: 10.1007/s430-001-8018-5
Keywords
Staphylococcus aureus; intercellular adhesin locus; polysaccharide intercellular adhesin; biofilm; prosthetic joint infection
Categories
Funding
- NIAID NIH HHS [AI-01647] Funding Source: Medline
Ask authors/readers for more resources
Although polysaccharide intercellular adhesin (PIA) is thought to be crucial in the pathogenesis of prosthetic device infections caused by Staphylococcus epidermidis, its role in prosthetic device infections caused by Staphylococcus aureus is unknown. To assess the clinical impact of PIA production, isolates from 15 prospectively identified cases of S. aureus bacteremia in patients with prosthetic joints (8 infected, 7 uninfected) were characterized for biofilm production, hemagglutination, and the presence of a 419-bp amplification product within icaA. Although icaA was present in ail 15 isolates, none of the isolates produced hemagglutination and only one isolate (from a patient with an uninfected prosthetic device) weakly produced biofilm in vitro. These results support the observation that the ica locus is conserved between S. epidermidis and S. aureus and that PIA may be expressed only under in vivo conditions. Future investigations should include animal models to approximate the complex milieu surrounding implanted prosthetic medical devices.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available