Journal
BIOCHEMISTRY
Volume 51, Issue 32, Pages 6289-6311Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi3006169
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Funding
- National Institute of General Medical Sciences
- National Institute of Neurological Disorders and Stroke
- American Health Assistance Foundation
- Glenn Foundation
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Copper is a redox-active metal with many important biological roles. Consequently, its distribution and oxidation state are subject to stringent regulation. A large body of clinicopathological, circumstantial, and epidemiological evidence suggests that the dysregulation of copper is intimately involved in the pathogenesis of Alzheimer's disease. Other light transition metals such as iron and zinc may affect copper regulation by competing for copper binding sites and transporters. Therapeutic interventions targeting the regulation of copper are promising, but large gaps in our understanding of copper biochemistry, amyloidogenesis, and the nature of oxidative stress in the brain must be addressed.
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