Journal
BIOCHEMISTRY
Volume 51, Issue 26, Pages 5232-5234Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi300535a
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Funding
- National Institute of Health [1R01CA161158]
- Welch Foundation [A-1715]
- National Science Foundation [DBI0821700]
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Using an evolved pyrrolysyl-tRNA synthetase-tRNA(Pyl) pair, a Se-alkylselenocysteine was genetically incorporated into histone H3 with a high protein expression yield. Quantitative oxidative elimination of Se-alkylselenocysteine followed by Michael addition reactions with various thiol nucleophiles generated biologically active mimics of H3 with posttranslational modifications including lysine methylation, lysine acetylation, and serine phosphorylation.
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