Journal
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volume 67, Issue 4, Pages 1689-1692Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.67.4.1689-1692.2001
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Enterocin P is a pediocin-like, broad-spectrum bacteriocin which displays a strong inhibitory activity against Listeria monocytogenes. The bacteriocin was purified from the culture supernatant of Enterococcus faecium P13, and its molecular mechanism of action against the sensitive strain E. faecium T136 was evaluated. Although enterocin P caused significant reduction of the membrane potential (Delta Psi) and the intracellular ATP pool of the indicator organism, the pH gradient (Delta pH) component of the proton motive force (Deltap) was not dissipated. By contrast, enterocin P caused carboxyfluorescein efflux from E. faecium T136-derived liposomes.
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