Journal
PHARMACOGENETICS
Volume 11, Issue 3, Pages 265-268Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008571-200104000-00010
Keywords
clozapine; genotype; schizophrenia; serotonin receptor; serotonin transporter; weight change
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Clozapine-induced weight gain may impair health and affect patient compliance. The aim of this study is to investigate the relationship between the genetic variants of the serotonin system and clozapine-induced body weight change (BWC). Ninety-three treatment-resistant schizophrenic patients were weighed monthly for 4 months during clozapine treatment, At the conclusion of treatment, patients had gained an average of 2.4 kg body weight, with BWC ranging from -17.5 to +12.9 kg. The levels of the serotonin transporter variants, serotonin 2A serotonin 2C and serotonin 6, demonstrated no statistically significant relationship to BWC. Patients with a lower initial body mass index demonstrated a greater weight gain associated with clozapine treatment. Further exploration of the neurotransmitters implicated in the antipsychotic-induced BWC is important in order to reduce the morbidity and noncompliance associated with weight gain, Pharmacogenetics 11:265-268 (C) 2001 Lippincott Williams & Wilkins.
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