Journal
BIOCHEMISTRY-MOSCOW
Volume 66, Issue 4, Pages 351-368Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1023/A:1010293809553
Keywords
neutrophil chemotaxis; signal transduction; G protein-coupled receptors; P13 kinases; Rho family proteins; actin polymerization
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This review discusses current knowledge on signal transduction pathways controlling chemotaxis of neutrophils and similar cells. Most neutrophil chemoattractants bind to seven-transmembrane-Helix receptors. These receptors activate trimeric G proteins of the Gi class in neutrophils to initiate chemotaxis. Phospholipases CP, phosphoinositide 3-kinase gamma, and PH domain-containing proteins play various roles in signaling further downstream. The actin cytoskeleton is crucial for cell motility, and is controlled by Rho family GTP-binding proteins. PIP 5-kinase, LIM kinase, myosin light chain kinase and phosphatase, or WASP-like proteins may be important links between Rho GTPases and actin during chemotaxis. Newly emerging ideas on the regulation of the compass of chemotaxing cells, which may involve Cdc42 and certain PH domain-containing proteins, are also presented.
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