In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated, Cefotaxime {4 times the MIG) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.