Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 45, Issue 4, Pages 1281-1283Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.45.4.1281-1283.2001
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The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated, Cefotaxime {4 times the MIG) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.
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