Journal
ENDOCRINE
Volume 14, Issue 3, Pages 337-342Publisher
SPRINGER
DOI: 10.1385/ENDO:14:3:337
Keywords
cytosolic phospholipase A(2); luteolysis; rat; immunohistochemistry
Categories
Ask authors/readers for more resources
We investigated the expression and activity of cytosolic phospholipase A(2) (cPLA(2)) in the corpus luteum during spontaneous and induced luteolysis in pseudopregnant rats. In both models, luteal PLA(2) activity rose in association with functional regression and persisted during the following structural regression. Tissue concentration of prostaglandin F-2 alpha with a luteolytic potency showed a similar fluctuation. The enzyme activity was almost completely suppressed by a cPLA(2)-specific inhibitor. Expression of cPLA(2), analyzed by immunohistochemistry, became enhanced during luteolysis with preferential localization to phagocytotic and fibrotic replacement sites. Taken together with our previous finding, the data indicate a persistent elevation in luteal cPLA(2) expression and activity that may affect tissue involution in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available