Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 73, Issue 3, Pages 271-277Publisher
SPRINGER JAPAN KK
DOI: 10.1007/BF02981951
Keywords
Jak kinase; STAT; cytokine; receptor; signaling
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The Janus family tyrosine kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway is broadly used by interferons and type I cytokines. These cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are cytosolic proteins. after activation, however. they are translocated to the nucleus where they function as transcription factors. This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo. (C) 2001 The Japanese Society of Hematology.
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