Journal
MICROBES AND INFECTION
Volume 3, Issue 4, Pages 323-332Publisher
EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/S1286-4579(01)01386-7
Keywords
HLA-G; innate immunity; placenta; pregnancy; CD8
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Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interaction with CD94/NKG2 receptors. HLA-G also down-modulates both CD8(+) and CD4(+) T-cell responsiveness. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
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