Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 225, Issue 1-2, Pages 301-307Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0304-8853(00)01254-3
Keywords
tumor cells; breast cancer; ferrofluids; magnetic loading; blood purification; rare cell extraction; non-specific binding
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Immune-magnetic selection of rare cells in blood has been optimized by increasing the magnetic loading of target cells and reducing the non-specific binding to non-target cells. Recovery of tumor cells spiked into normal blood ranged from 60 to 90% and is linear over a range of 1-200cells/ml. Tumor cells were found in peripheral blood of breast cancer patients and their numbers increase with disease progression. (C) 2001 Published by Elsevier Science B.V.
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