Journal
BIOCHEMISTRY
Volume 50, Issue 14, Pages 2994-3003Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi101981z
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Funding
- Italian Space Agency
- Italian Space Agency National Institute for Astrophysics [I/015/07/0]
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We report two reactions of RNA G:C sequences occurring nonenzymatically in water in the absence of any added cofactor or metal ion: (a) sequence complementarity-driven terminal ligation and (b) complemental), sequence adaptor-driven multiple tandemization. The two abiotic reactions increase the chemical complexity of the resulting pool of RNA molecules and change the Shannon information of the initial population of sequences.
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