Journal
BIOCHEMISTRY
Volume 50, Issue 5, Pages 599-601Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi101896j
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Funding
- National Institutes of Health [3R01GM-079235-02S1, 1R01GM079235-01A2]
- Research Corp.
- Dreyfus New Faculty
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The NMR structure of an RNA with a copy of the 5'CUG/3'GUC motif found in the triplet repeating disorder myotonic dystrophy type 1 (DM1) is disclosed. The lowest energy conformation of the UU pair is a single-hydrogen bond structure; however, the UU protons undergo exchange indicating structural dynamics. Molecular dynamics simulations show that the single hydrogen bond structure is the most populated one but the UU pair interconverts among zero, one, and two hydrogen bond pairs. These studies have implications for the recognition of the DM1 RNA by small molecules and proteins.
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