Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 11, Issue 2, Pages 136-141Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(00)00170-2
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De novo nucleosome assembly coupled to DNA replication and repair in vitro involves the histone chaperone chromatin assembly factor 1 (CAF-I). Recent studies support a model in which CAF-1 can be targeted to newly synthesized DNA through a direct interaction with proliferating cell nuclear antigen (PCNA) and can act synergistically with a newly identified histone chaperone. Insights have also been obtained into mechanisms by which this CAF-1-dependent pathway can establish a repressed chromatin state.
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