Journal
BIOCHEMISTRY
Volume 49, Issue 17, Pages 3511-3513Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi100430s
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- The Netherlands Organization for Scientific Research (NWO)
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The Na+ aspartate symporter Glt(Ph) from Pyrococcus horikoshil is the only member of the glutamate transporter family for which crystal structures have been determined. The cation:aspartate coupling stoichiometry is unknown, thus hampering the elucidation of the ion coupling mechanism. Here we measure transport of Na-22(+) and [C-14]aspartate in proteoliposomes containing purified Glt(Ph) and demonstrate that three Na+ ions are symported with aspartate.
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