Journal
PHYTOCHEMISTRY
Volume 56, Issue 8, Pages 857-861Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9422(00)00402-7
Keywords
Zanthoxylum tetraspermum; Z. caudatum; Rutaceae; benzophenanthrene alkaloids; 8-acetonyldihydronitidine; 8-acetonyldihydroavicine; antimicrobial; spermicidal; insecticidal
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Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma -dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihyronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity. (C) 2001 Published by Elsevier Science Ltd.
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