Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 1, Issue 4, Pages 665-675Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-5769(00)00051-5
Keywords
cocaine; lymphocyte proliferation; local anaesthetic; monoamine reuptake inhibitor; HPA axis; corticosterone
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Funding
- NIDA NIH HHS [DA05849] Funding Source: Medline
- NIMH NIH HHS [MH11589] Funding Source: Medline
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Cocaine has previously been shown to decrease mitogen-induced T lymphocyte proliferation in rats following intravenous administration. However, in this report, it is demonstrated that central administration of cocaine (1-50 mug) had no effect on lymphocyte proliferation responses. Similarly, the quaternary derivative, cocaine methiodide, also suppressed lymphocyte proliferation only when administered peripherally (6.5 mg/kg), and not centrally (1-20 mug) These results suggest that the effects of cocaine were mediated through a peripheral mechanism. Since significant elevations in plasma corticosterone were observed with all routes of administration of cocaine. the effects of cocaine did not appear to be due entirely to activation of the HPA axis. Instead, the peripheral administration of the local anesthetic, lidocaine (5 mg/kg) or the monoamine reuptake inhibitor. RTI-55 (2-5 mg/kg), produced significant suppressive effects on proliferation, suggesting that both of these peripheral activities of cocaine may be involved in the alteration of lymphocyte responses. (C) 2001 Elsevier Science B.V. All rights reserved.
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