Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 12, Issue 2, Pages 139-148Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/scdb.2000.0231
Keywords
flipflop; lipid asymmetry; translocase; flippases; ABC transporter
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In eukaryotic cells, the membranes of different intracellular organelles have differ ent lipid composition, and various biomembranes show an asymmetric distribution of lipid types across the membrane bilayer Membrane lipid organization reflects a dynamic equilibrium of lipids moving across the bilayer in both directions. In this review, we summarize data supporting the role of specific membrane proteins in catalyzing transbilayer lipid movement, thereby controlling and regulating the distribution of lipids over the leaflets of biomembranes.
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