Journal
IMMUNOGENETICS
Volume 53, Issue 3, Pages 209-214Publisher
SPRINGER
DOI: 10.1007/s002510100319
Keywords
Clr; natural killer; NKC; LLT1; lectin
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We report the identification of a novel family of genes, named Clr, encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6. Genomic sequence analysis indicates the presence of at least seven members between Nkrp1a and Cd69. By RT-PCR, at least three members of the family are expressed on interleukin-2-activated NK cells. Sequence analysis revealed complete open reading frames of 203-205 amino acids, with a carboxyl-terminal C-type lectin-like carbohydrate recognition domain (CRD). The CRDs of the Clr proteins exhibit a significant degree of homology with the known NKC-encoded NK-cell receptors. However, a key cysteine usually present in the CRD is missing in the Clr proteins, suggesting that their ligands and functions proteins, suggesting that their ligands and functions are distinct from other molecules encoded in the NKC.
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