Journal
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Volume 26, Issue 2, Pages 81-85Publisher
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2710.2001.00330.x
Keywords
analgesics; antihistamine; histamine; neuropeptides; pain
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Histamine activates pain-transmitting nerve fibres, releases pain-related neuropeptides, and is painful when injected into the skin. Histamine agonists mimic these effects, suggesting that histamine plays a role in mediating the signal transduction of tissue damage or other painful stimulus. Certain 'antihistamines' (histamine H-1 receptor antagonists) and other antihistaminics are 'analgesic' in preclinical or clinical models. Potential sites of action of these agents include the brain and spinal cord and a specific histamine receptor subtype might be involved (three subtypes have been identified). However, it is possible that other mechanisms account for the analgesic effect.
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