Journal
BIOCHEMISTRY
Volume 48, Issue 33, Pages 7817-7823Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi9006786
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Funding
- National Science Foundation of China [20775082, 90717119]
- 973 Program [2007CB935601]
- 863 Program [2008AA02Z206]
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DNA sequences with repetitive G-rich structural motifs, which form special structures called G-quadruplexes, widely exist in the human genome. Here we report the general peroxidase activity of G-quadruplex-hemin complexes and discuss the connection between peroxidase activity and G-quadruplex structures. The high peroxidase activity of hemin complexed with intramolecular parallel G-quadruplex-forming sequences in gene promoters (such as c-Myc, VEGF, c-Kit21, HIF-1 alpha, and RET) may imply a potential mechanism of hemin-mediated cellular injury. This peroxidase activity has also been demonstrated to be applicable for screening G-quadruplex ligands (potential anticancer reagents) using colorimetric and Visual detection strategies.
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