Journal
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
Volume 33, Issue -, Pages 85-89Publisher
WILEY
DOI: 10.1042/BA20000087
Keywords
corticosteroids; drug delivery; erythrocytes
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Human erythrocytes from ten patients with chronic obstructive pulmonary disease (COPD) were loaded with increasing amounts of dexamethasone 21-phosphate and were re-infused into the original donors. Drug-loaded erythrocytes acted as circulating bioreactors, converting the non-diffusible dexamethasone 21-phosphate into the diffusible dexamethasone. Pharmacokinetic analyses on these patients showed that a single administration of drug-loaded erythrocytes was able to maintain detectable dexamethasone concentrations in blood for up to seven days. This continuous release of dexamethasone was paralleled by the suspension of beta (2)-agonist and oral corticosteroid treatments by all of the patients,Thus dexamethasone 21-phosphate-loaded erythrocytes are safe carriers for corticosteroid analogues and are a useful alternative to frequent oral or inhaled drugs in elderly patients with COPD.
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