4.6 Article

Regression of a murine gammaherpesvirus 68-positive B-cell lymphoma mediated by CD4 T lymphocytes

Journal

JOURNAL OF VIROLOGY
Volume 75, Issue 7, Pages 3480-3482

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.7.3480-3482.2001

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Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T lymphocytes were most effective in preventing tumor formation, and immunohistochemistry highlighted populations of CD4 T cells in regressing tumors.

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