Journal
CELL DEATH AND DIFFERENTIATION
Volume 8, Issue 4, Pages 403-410Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4400827
Keywords
APRIL (a proliferation-inducing ligand); apoptosis; glioma; death ligands; CD95L; TRAIL/Apo2L
Categories
Ask authors/readers for more resources
APRIL ((a) under bar (pr) under bar oliferation-(i) under bar nducing (l) under bar igand) is a newly identified member of the tumor necrosis factor (TNF) family. Tumor growth-promoting as well as apoptosis-inducing effects of APRIL have been described, Here, we report that five of 12 human malignant glioma cell lines express APRIL. APRIL gene transfer experiments revealed that malignant glioma cells are refractory to growth-promoting activity of APRIL in vitro and in vivo. Interestingly, ectopic expression of APRIL confers minor protection from apoptotic cell death induced by the death ligands, CD95 ligand (CD95L) and tumor necrosis factor related apoptosis-inducing ligand (TRAIL)/Apo2 ligand (Apo2L), This antiapoptotic activity is specific for death ligand/receptor-mediated apoptosis since APRIL does not protect glioma cells from the cytotoxicity of the drugs, teniposide, vincristine, lomustine or cisplatin, Ectopic expression of APRIL is associated with the upregulation of X-linked inhibitor of apoptosis protein (XIAP), providing a possible explanation for the antiapoptotic activity observed here. In contrast, APRIL does not regulate the expression levels of the antiapoptotic proteins FLICE-inhibitory protein (FLIP), Bcl-2 or Bcl-X-L. These findings suggest that APRIL is involved in the regulation of death ligand-induced apoptotic signaling in malignant glioma cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available