Journal
BIOCHEMISTRY
Volume 48, Issue 46, Pages 10830-10845Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi901656f
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Funding
- Canada Research Chair in Metalloproteinase Proteomics and Systems Biology
- Canadian Institutes of Health Research
- National Cancer Institute of Canada
- Canadian Breast Cancer Research Alliance Metastasis
- Michael Smith Research Foundation
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Shotgun proteomics techniques are conceptually unbiased, but data interpretation and follow-Lip experiments are often constrained by dogma, established beliefs that are accepted without question, that can dilute the power of proteomics and hinder scientific progress. Proteomics and degradomics, the charactenzation of all proteases, inhibitors, and protease substrates by genomic and proteomic techniques, have exponentially expanded the known substrate repertoire of the matrix metalloproteinases (MMPs), even to include intracellular proteins with newly recognized extracellular functions. Thus, the dogma that MMPs are dowdy degraders of extracellular matrix has been resolutely overturned, and the metamorphosis of MMPs into modulators of multiple signaling pathways has been facilitated. Here we review progress made in the Field of degradomics and present a current view of the MMP degradome.
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