3.8 Article

Hydrolysis of oligodeoxynucleotide phosphodiester linkages

Journal

SCIENCE IN CHINA SERIES B-CHEMISTRY
Volume 44, Issue 2, Pages 169-174

Publisher

SCIENCE PRESS
DOI: 10.1007/BF02879534

Keywords

cerium ion; oligodeoxynucleotide (ODN); hydrolysis; electrophoresis; enhanced Raman scattering

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The hydrolysis of 26-mer oligodeoxynucleotide (26-mer ODN) by cerium ions is reported. The process was analyzed by electrophoresis and the surface enhanced Raman scattering spectroscopy (SERS). Ce3+ could be oxidized to Ce4+ in oxygen atmosphere, and only Ce4+ could be used in the cleavage of ODN. We systematically studied the hydrolysis of ODN in Various conditions.

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