Journal
NEUROPSYCHOPHARMACOLOGY
Volume 24, Issue 4, Pages 430-440Publisher
NATURE PUBLISHING GROUP
DOI: 10.1016/S0893-133X(00)00210-4
Keywords
serotonin; amygdala; anxiety conflict; ethanol consumption; locomotion
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several serotonergic drugs are effective for anxiety disorders but underlying mechanisms are unclear, adn findings in experimental animals are difficult to reconcile with human data. It has been proposed that differential effects of serotonin within specific anatomical systems may account for these difficulties, and the amygdala has been suggested as one of the structures involved. To examine this hypothesis, the neurotoxin 5,7-dihydroxytryptamine was administered locally in rat amygdala. Within the amygdala, serotonin was depleted by approximately 80%, with other transmitters unaffected and serotonin transporter labelling was decreased by approximately 85%. Cortical areas near the lesion site were also affected, although to a lesser degree. Other forebrain areas were unaffected. Lesion resulted in a specific anti-conflict effect in a punished drinking test, but did not influence elevated plus-maze behavior (under basline conditions and after restraint stress), locomotor activity or ethanol intake. These data suggest that the punished drinking test and the elevated plus-maze may activate different components of fear circuitry, and that the serotonergic input to the amygdala specifically participates in fear-related behavioral suppression mediated by this structure. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
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