Journal
NEURON
Volume 30, Issue 1, Pages 227-240Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(01)00275-6
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Funding
- NIMH NIH HHS [MH53603] Funding Source: Medline
- NINDS NIH HHS [NS12333] Funding Source: Medline
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Newly synthesized Are mRNA is selectively targeted to synapses that have experienced particular patterns of activity. Here, we demonstrate that the targeting requires NMDA receptor activation. Are expression was induced by an electroconvulsive seizure, and the newly synthesized mRNA was then targeted to synaptic sites by activating the perforant path projections to the dentate gyrus. When micropipette electrodes containing NMDA receptor antagonists (MK801 or APV) were positioned in the dentate gyrus during the stimulation period, newly synthesized Are mRNA was transported into dendrites but did not localize in the activated lamina; instead, the mRNA remained diffusely distributed. AMPA receptor antagonists (CNQX) blocked targeting of Are mRNA in a small region, and mGluR antagonists (MCPG) did not affect localization. These results demonstrate that NMDA receptor activation is required for the targeting of Are mRNA to active synapses.
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