Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 11, Issue 2, Pages 182-188Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(00)00177-5
Keywords
-
Categories
Ask authors/readers for more resources
Centromeres provide a distinctive mechanical function for the chromosomes as the site of kinetochore assembly and force generation in mitosis and meiosis. Recent studies show that a unique form of chromatin, based on the histone-H3-like protein CENP-A and homologues, provides a conserved foundation for this mechanical chromatin domain. CENP-A plays a role in templating kinetochore assembly and may be a central element in the epigenetic maintenance of centromere identity. Cohesion at the centromere, intimately linked to kinetochore assembly, is required for integrating spindle forces exerted across the centromere and for establishing the bipolar geometry of sister kinetochores.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available