Journal
SEMINARS IN CANCER BIOLOGY
Volume 11, Issue 2, Pages 97-104Publisher
ACADEMIC PRESS LTD
DOI: 10.1006/scbi.2000.0361
Keywords
carcinogenesis; genomic instability; stromal-epithelial interactions; carcinoma-associated fibroblasts; reactive stroma
Categories
Ask authors/readers for more resources
The majority of studies of neoplastic transformation have focused attention on events that occur within transformed cells. These cells autonomous events result in the disruption of molecular pathways that regulate basic activities of the cells such as proliferation, death, movement and genomic integrity. Other studies have addressed the microenvironment of tumor cells and documented its importance in supporting tumor progression. Recent work has begun to expand on these initial studies of tumor microenvironment and now provide novel insights into the possible initiation and progression of malignant cells. This review will address the transforming effect of stromal cells on epithelial components.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available