Journal
NATURE IMMUNOLOGY
Volume 2, Issue 4, Pages 346-352Publisher
NATURE AMERICA INC
DOI: 10.1038/86354
Keywords
-
Categories
Funding
- NIAID NIH HHS [AI-15136, R29 AI034431, R29 AI034431-05] Funding Source: Medline
- NIGMS NIH HHS [GM-28485, GM-37696] Funding Source: Medline
Ask authors/readers for more resources
Leptospira interrogans are zoonotic pathogens that have been linked to a recent increased incidence of morbidity and mortality in highly populated tropical urban centers. They are unique among invasive spirochetes in that they contain outer membrane lipopolysaccharide (LPS) as well as lipoproteins. Here we show that both these leptospiral outer membrane constituents activate macrophages through CD14 and the Toll-like receptor 2 (TLR2). Conversely, it seems that TLR4, a central component for recognition of Gram-negative LPS, is not involved in cellular responses to L. interrogans. We also show that for intact L. interrogans, it is LPS, not lipoprotein, that constitutes the predominant signaling component for macrophages through a TLR2 pathway. These data provide a basis for understanding the innate immune response caused by leptospirosis and demonstrate a new ligand specificity for TLR2.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available