Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 12, Issue 2, Pages 99-106Publisher
ACADEMIC PRESS LTD
DOI: 10.1006/scdb.2000.0238
Keywords
axon guidance; dendritic spine; heparan sulfate proteoglycan; neurogenesis; synapse
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Development of the mammalian nervous system involves generation of neurons from neural stem cells, migration of generated neurons toward genetically determined locations, extension of axons and dendrites, and establishment of neuronal connectivity. Recent progresses revealed diverse role Of heparan sulfate proteoglycans in these processes. This article reviews our current knowledge about the functional roles of heparan sulfate proteoglycans in three critical events in mammalian neural development, namely neurogenesis, axon guidance, and synapse development.
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