Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 26, Issue 17, Pages 1286-1296Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2015.1088125
Keywords
tissue engineering scaffold; hydrophilicity; poly(lactic acid); polyethylene glycol; amphiphilic block polymer; phase separation
Funding
- National Natural Science Foundation of China [51173104]
- Nanotechnology Program of Science and Technology Committee of Shanghai [11nm0503500]
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Porous poly(lactic acid) (PLA) tissue engineering scaffolds with a hydrophilic surface assembled by polyethylene glycol aggregations were prepared by the solvent casting/particulate leaching method from (PLA)-(PLA-b-PEG)-(PEG) blend solution, where the PLA-b-PEG block polymer serves as an amphiphilic glue between two phases. A thermal recrystallization process was inserted before leaching to induce a phase separation, which subsequently squeezes out PEG to form a hydrophilic shell. Characterizations of XRD and DSC indicated the composition and mixing states of materials. The water contact angle test qualitatively presented the excellent hydrophilicity compared to the pure PLA or PLA-PEG simple blend scaffold. The scanning electron microscope results confirmed the formation of porous structure of pore size, with an observable phase separation on the surface. The scaffold was degraded in PBS at graphic, and the degradation exhibits a three-stage behavior, which evidenced the amphiphilically glued phase separations.
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