Journal
KIDNEY INTERNATIONAL
Volume 59, Issue 4, Pages 1227-1235Publisher
BLACKWELL SCIENCE INC
DOI: 10.1046/j.1523-1755.2001.0590041227.x
Keywords
complement cascade; protein synthesis; gene expression of complement; renal complement system; pathogenesis of renal disease; immune complexes
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During the past decade, research has shown that the kidney has the capacity to synthesize most of the activation pathway components of the complement cascade. As well as implying physiological roles in local clearance of immune complexes and defense against invasive organisms, an increasing amount of evidence indicates that the intrarenal synthesis of complement makes an important contribution in the pathogenesis of renal injury. Here we review this evidence and present a case for more definitive investigation of these functions.
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