Journal
BIOCHEMISTRY
Volume 47, Issue 9, Pages 2732-2742Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi7021014
Keywords
-
Categories
Ask authors/readers for more resources
We have explored the stability of selected ribo oligomers in water and have determined the physical-chemical conditions in which the key 3 '-phosphoester bond is more stable when embedded in the polymer than when present in the monomer. In these conditions, the spontaneous formation and the survival of ribo polymers are potentially favored. A narrow pH range was identified in which complex sequences resist degradation markedly more than monotonous ones, thus potentially favoring the evolution of sequence-based genetic information. Given that the founding property of a polymer is to maintain its polymeric form and its sequence information, these findings support the view that the evolution of pregenetic molecular information occurred based on intrinsic properties of nucleic polymers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available