Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 30, Issue 7, Pages 1071-1079Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328215613886
Keywords
Alginate; chitosan; polyelectrolyte complex; coacervation; wound healing
Funding
- Egyptian Academy of Scientific Research and Technology as a part of the SNG grant program
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Polyelectrolyte complexes represent a special class of polymeric compounds consisting of stoichiometric equivalents of oppositely charged polyions interacting together spontaneously to yield a complex in different forms. The present study aimed at preparing coacervates of alginate and chitosan polymers ready for casting as wound dressing films. This was based on controlling the pH of solutions and the reactions speed through controlling the rate of mixing of the polymers solutions together without using any water-miscible solvents. Alginate was modified with radiation and oxidation, and the interactions of the resulting chains and chitosan chains were tested with FTIR spectroscopy and scanning of the resulting films with SEM. This work showed the ability to prepare a complex of highly connected polymeric chains for further biomedical applications. This complex in the form of hydrogel could enhance the proliferation of cells invitro and the healing efficiency with accelerating the wound closure rate as evidenced through the histological observations.
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