Journal
BRITISH JOURNAL OF CANCER
Volume 84, Issue 7, Pages 878-880Publisher
NATURE PUBLISHING GROUP
DOI: 10.1054/bjoc.2000.1472
Keywords
adjuvant chemotherapy; epidoxorubicin; 5-fluorouracil; gastric cancer; leucovorin; randomized trial
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Adjuvant chemotherapy of gastric cancer after curative resection is still subject to discussion. In this study 137 patients with gastric adenocarcinoma, all with positive nodes, were randomized after curative resection so that 69 received epidoxorubicin (EPI), leucovorin (LV) and 5-fluorouracil (5-FU) on days 1-3 every 3 weeks for 7 months, whereas the remaining 68 did not, After a follow-up period of 5 years, 21 of the 69 treated patients (30%) and nine controls (13%) were still alive; median survival time was 18 months for the controls and 31 months for the patients treated with adjuvant chemotherapy (P < 0.01). (C) 2001 Cancer Research Campaign.
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