Journal
SCIENCE
Volume 292, Issue 5514, Pages 104-106Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1057991
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The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. in the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median Life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of Life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of Life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.
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