Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 282, Issue 3, Pages 839-843Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2001.4639
Keywords
inositol phosphatase; phosphatidylinositol metabolism; signal transduction
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The lipid phosphatase SHIP2 ((SH) under bar2 domain containing (i) under bar nositol 5-(p) under bar hosphatase (2) under bar) has recently been shown to be a potent negative regulator of insulin signaling and insulin sensitivity in vivo, We show here that SHIP2 is expressed in Chinese hamster ovary cells overexpressing the insulin receptor (CHO-IR cells) and tyrosine phosphorylated upon insulin stimulation. We show that SHIP2, which is recruited in antiphosphotyrosine immunoprecipitates in insulin-stimulated cells, accounts for the insulin sensitivity or apparent increase in activity reported by Guilherme et al, (J. Biol. Chem, 271, 29533-29536, 1996), Overexpression of SHIP2 led to a decrease of the insulin-dependent PIP3 production as well as Akt/PKB activation and MAPK stimulation. (C) 2001 Academic Press.
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