Journal
TOXICOLOGY LETTERS
Volume 121, Issue 1, Pages 79-85Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0378-4274(01)00325-3
Keywords
TDI; skin sensitivity; airways; guinea pigs
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Toluene diisocyanate (TDI), a highly reactive industrial chemical is a leading cause of occupational asthma in westernized countries. It has also been reported to be a skin sensitizer in mice and guinea pies although instances of skin sensitivity in humans are rare. It is uncertain if skin-contact is necessary to initiate the dermal sensitization. This study sought to determine if exclusive airway exposure to TDI could result in skin sensitivity. A group of guinea pigs was administered 50 mul or 0.6% TDI intratrachrally (it.). another group received intranasal (in.) application of 0.6. 1.2, or 1.8% TDI. Eighty percent (4/5) of the it.-dosed animals, and 92% (11/12) of in.-dosed animals exhibited skin sensitivity. None of 14 control animals gave a positive reaction to patch challenge with TDI, These findings indicate that exclusive exposure of the airways to TDI can result in skin sensitivity and suggest that such events may be possible in TDI workers and should be considered in all workers exposed via the airways to chemical sensitizers. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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