Journal
AMERICAN JOURNAL OF MEDICAL GENETICS
Volume 105, Issue 3, Pages 279-282Publisher
WILEY-LISS
DOI: 10.1002/ajmg.1323
Keywords
obsessive-compulsive disorder; gender subtype; monoamine oxidase A gene; association studies
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Studies have recently reported a sexually dimorphic association between obsessive-compulsive disorder (OCD) and a polymorphism related with variations in MAO-A activity. These observations suggest the possibility of gender differences in genetic susceptibility for OCD. We thus reexamined the MAO-a/EcoRV polymorphism in a sample of 122 OCD patients and 124 healthy subjects, An excess of allele 1 in OCD females with major depression disorder was confirmed as previously reported. This difference was more strongly associated with OCD females than males in the total sample, Finally, we analyzed a sample of 51 OCD trios. Haplotype-based haplotype relative risk (HHRR) analysis of the inheritance of the MAO-A variants revealed in the female probands that 14 out of 19 transmitted the allele 1, providing significant evidence for an allelic association between OCD and MAO-A gene, In conclusion our findings may provide molecular evidence to identify a clinically meaningful gender subtype. However, an effort should be made to replicate the analysis' in larger samples of informative parents using strategies such as transmission disequilibrium test to allow definite conclusions. (C) 2001 Wiley-Liss, Inc.
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