Phenolic constituents from the roots of Rosa laevigata (Rosaceae)

Chemical investigation of the root of Rosa laevigata led to the isolation of sixteen phenolic compounds, including seven flavonoids (1-7), five condensed tannins (8-12), two stilbenes (13 and 14) and two benzoic acid derivatives (15 and 16). Their structures were identified as (+)-catechin (1), (+)-gallocatechin (2), (2R, 3S, 45)-cis-leucocyanidin (3), (2R, 3S, 4S)-cisleucofisetinidin (4), (2S, 3R, 4R)-cis-leucofisetinidin (5), dehydrodicatechin A (6), phloridzin (7), procyanidin B3 (8), fisetinidol-(4 alpha, 8)-catechin (9), guibourtinidol- (4 alpha, 8)-catechin (10), ent- isetinidol -(4 alpha, 6)-catechin (11), fisetinidol-(4 beta, 8)-catechin (12), (Z)-3-methoxy-5hydroxy- stilbene (13), (Z)-piceid (14), gallic acid (15) and 4-hydroxybenzoic acid- 4-o-beta-D-glucopyranoside (16). Among them, compounds 3-7, 9-14, and 16 were isolated from R. laevigata for the first time, and compounds 3-7,9,10,12-14 and 16 were reported for the first time from the genus Rosa. The chemotaxonomic significance of these compounds was summarized. (c) 2013 Elsevier Ltd. All rights reserved.